A Theory of Genre Formation in the Twentieth Century

In his article "A Theory of Genre Formation in the Twentieth Century" Michael Rodgers explores the relationship between Vladimir Nabokov's Invitation to a Beheading and magical realism in order to theorize about genre formation in the twentieth century. Rodgers argues not only that specific twentieth-century narrative forms are bound intrinsically with literary realism and socio-political conditions, but also that these factors can produce formal commonalities

1999 Vermont remote sensing study

Issued as final reportFinal report has title: 1999 Vermont remote sensing study

Sinkhole Analysis and Classification Using Pictometry in Genesee County, NY and Surrounding Areas

Oblique Imagery was used to assess 250 depressional features within the carbonate bedrock region of Genesee County, NY and surrounding areas. Of these features, 110 were confirmed to be sinkholes. The analysis of Pictometry Oblique Imagery, with images spanning the past 15 years, was performed to sample each individual sinkhole for each available time-step image. Parameters were created using GIS-based data and imagery characteristics, and statistically analyzed for confirmed sinkholes to assess similarities and differences between the sinkholes. A cluster analysis showed that there is a relationship between sinkholes and a variety of GIS data types. These statistically derived associations suggest that the following factors are indicative of sinkholes: Visible Depression, Secondary Characteristics, Target Soil Presence/Absence, Moisture Content, Land Use, Type (water/land), Size, and Shape. The study suggested that distance from visible escarpments and bedrock geology, two guidelines for finding karst features suggested by previous studies, were not statistically correlated to sinkholes in Genesee County and surrounding areas

Wittgenstein and Nietzsche on the Role of Philosophy: Description, Creativity, Naturalism, and Possibility

This dissertation places Wittgenstein and Nietzsche alongside one another in an attempt to deal with the question: what is the role of the philosophy? On the one hand Wittgenstein promotes a descriptive approach to philosophy, which insists that the philosopher should not meddle with practices but rather seek clarity and understanding as ends in themselves. On the other hand Nietzsche promotes a destructive and creative approach to philosophy, where the philosopher both dismantles values and offers a revaluation of values in their place. This work begins with a survey of remarks by the two philosophers and prominent interpretations of them on how best to conceive of and understand the philosopher and philosophy. In addition, the recent view of Nietzsche as a naturalist is responded to at length. If Nietzsche turns out to be offering substantive, naturalistic positions on human morality, the origins of religion, and so on, then he cannot be advocating a creative, spontaneous orientation towards perspectives. This work argues that while Nietzsche offers naturalized accounts of human practices, he does not mean these to be considered scientific hypothesis. After responding to this position, Nietzsche and Wittgenstein are looked at together, and what emerges is a shared goal: the creating and/or revealing of missed possibilities of human life. These existential possibilities are on the one hand always right in front of us, and yet they are seemingly out of reach and all too often passed over. Wittgenstein and Nietzsche, in their various ways, (re)open these possibilities. Finally, given this hermeneutics of possibility, the final chapter argues that the way Wittgenstein and Nietzsche differ with respect to Christianity and religion is not primarily about their style of philosophy nor even about Wittgenstein\u27s descriptive approach, but about the existential possibility that each has in mind to promote

Mechanisms and consequences of ATM activation

Mutations in the ataxia telangiectasia mutated (ATM) gene cause the disease ataxia-telangiectasia (A-T). Patients with this disease have multiple symptoms, including the eponymous ataxia and telangiectasia as well as immunodeficiency, radiation sensitivity, and increased cancer rates. The ATM protein is a kinase and is activated by multiple types of stress to affect many cellular processes. At sites of DNA double-strand breaks (DSBs), ATM is activated by the protein complex Mre11/Rad50/Nbs1 (MRN). As part of this complex, Rad50 binds and hydrolyzes ATP and causes large conformational changes in the complex. However, the importance of this enzymatic activity in the activation of ATM has been unknown. Here I show ATP binding by Rad50 is required for ATM activation while ATP hydrolysis is dispensable. ATM is also activated in the presence of oxidative stress. Separation-of-function mutations for the activation of ATM by DSBs and oxidative stress have been characterized in vitro. Here, the effects of expressing wild-type ATM or ATM with these different separation-of-function mutations in an ATM-deficient lymphoblast cell line have been characterized. Analysis of the proteomes of these cells and a control cell line revealed that non-functional ATM resulted in the loss of a large group of proteins by mass spectrometry. The levels of these proteins were similar in the cells, but in the presence of non-functional ATM they showed increased levels of aggregation. Thus my results suggest ATM may function to prevent aggregation in these conditions. Notably neurodegeneration is often associated with aggregation. In the phosphoproteomes of cells expressing the various ATM constructs, the parental cell line and cells with ATM unable to be activated by oxidative stress had lower levels of phosphopeptides predicted to be phosphorylated by CK2. This decrease in CK2 activity was also associated with increased aggregation, specifically a subunit of CK2 known as CK2β. This work provides insights into the mechanism of ATM activation by MRN and the potential involvement of ATM in the prevention of protein aggregation.Cellular and Molecular Biolog

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Editorial 24, 1 (2021)Éditorial 24, 1 (2021

An Unsuccessful Urban Deep Excavation in Soft Soils

This case history presents, from a geotechnical engineer\u27s viewpoint, various technical, budgetary, coordination, staffing and hidden agenda issues that contributed to poor performance of a shored deep excavation 10 soft soils. The anticipated and actual construction procedures are discussed and compared. In addition, approaches to stabilize significant movements of the shoring, and the methodology needed to justify a satisfactory future performance of a pile foundation system that was speculated to be damaged are discussed. By highlighting these issues, it is hoped geotechnical engineers will anticipate and better deal with the issues under their influence, understand issues over which they may not have control, and appreciate the need for mutual understanding and cooperation by members of the design team